SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF N'-(2-HYDROXY-5-NITROBENZYLIDENE) ISONICOTINOHYDRAZIDE
Ключевые слова:
isonicotinic acid, hydrazones, chemical modification, antimicrobial activity.Аннотация
The paper presents data on the synthesis, structure and bioactivity of N '- (2-hydroxy-5-
nitrobenzylidene) isonicotinohydrazide based on isonicotinic acid hydrazide. The structure of the new hydrazone was
studied by 1
H and 13C NMR spectroscopy, as well as two-dimensional COSY (1
H-1
H) and HMQC (1
H-13C) spectra.
The values of chemical shifts, multiplicity and integral intensity of 1
H and 13C signals in one-dimensional NMR
spectra are determined. Using spectra in COSY (1
H-1
H) and HMQC (1
H-13C) formats, homo- and heteronuclear
interactions have been established, confirming the structure of new isonicotinic acid derivatives. Studies of the
synthesized compound for antimicrobial activity against drug-sensitive museum strains of bacteria and fungi have
been carried out. According to the results of bioassays, it was shown that a new hydrazone derivative of isonicotinic
acid in a dose of 1 μg has a weak potential for antimicrobial activity, and the diameters of growth inhibition zones for
in vitro test cultures averaged 12 ± 1.0 mm.
